[Polymorphism of angiotensin-converting enzyme gene and susceptibility to asthma with familial aggregation].

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Article

[Polymorphism of angiotensin-converting enzyme gene and susceptibility to asthma with familial aggregation].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases - 1 Nov 1999

Gao J, Lin Y, Xiao Y

Abstract excerpt

OBJECTIVE: Angiotensin-converting enzyme (ACE) plays a key role in the metabolism of angiotensin II (AT II) and inactivation of bradykinins and tachykinins, which are potent bronchial constrictors and mediators of inflammation asthma, and ACE is heavily expressed in the lungs. An insertion-deletion (D/I) polymorphism of ACE gene has been shown to be associated with levels of ACE. Whether or not the polymorphism...

Topics

Adolescent
Adult
Aged
Asthma
Female
Genetic Markers
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Pedigree
Peptidyl-Dipeptidase A
Polymorphism, Genetic

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Open in PubMed

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PMID: 11776522

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