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Article

Familial medullary thyroid carcinoma: not a distinct entity? Genotype-phenotype correlation in a large family.

The American journal of medicine - 1 Dec 1996

Moers A M, Landsvater R M, Schaap C, Jansen-Schillhorn van Veen J M, de Valk I A, Blijham G H, Höppener J W, Vroom T M, van Amstel H K, Lips C J

Abstract excerpt

BACKGROUND: Multiple endocrine neoplasia type 2A (MEN 2A) is a hereditary syndrome characterized by medullary thyroid carcinoma (MTC), pheochromocytoma, and hyperparathyroidism. Familial MTC (FMTC) is characterized by MTC only. Both MEN 2A and FMTC are caused by germline mutations of the RET prot...

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Identifiers

PMID: 9003111
DOI: 10.1016/s0002-9343(96)00330-0

Genes

RET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-9003111-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Familial medullary thyroid carcinoma: not a distinct entity? Genotype-phenotype correlation in a large family.PMID 9003111Read ↗

A large family with hereditary MTC: role of RET genetic analysis in differential diagnosis between MEN 2A and FMTC.Semantic proximity Read ↗

Penetrance of inherited medullary thyroid carcinoma and genotype-phenotype correlation in a large multiple endocrine neoplasia type 2A family with C634Y RET mutation.Semantic proximity Read ↗

Hereditary Medullary Thyroid Cancer Genotype-Phenotype Correlation.Semantic proximity Read ↗

Mutations of the ret protooncogene in German multiple endocrine neoplasia families: relation between genotype and phenotype. German Medullary Thyroid Carcinoma Study GroupSemantic proximity Read ↗

RET proto-oncogene: a review and update of genotype-phenotype correlations in hereditary medullary thyroid cancer and associated endocrine tumors.Semantic proximity Read ↗

Mutations of the ret protooncogene in German multiple endocrine neoplasia families: relation between genotype and phenotype. German Medullary Thyroid Carcinoma Study Group.Semantic proximity Read ↗

Genetics of medullary thyroid cancer: An overview.Semantic proximity Read ↗

Comprehensive analysis of RET gene should be performed in patients with multiple endocrine neoplasia type 2 (MEN 2) syndrome and no apparent genotype-phenotype correlation: an appraisal of p.Y791F and p.C634Y RET mutations in five unrelated Brazilian families.Semantic proximity Read ↗

Genotype-phenotype relationship in multiple endocrine neoplasia type 2. Implications for clinical management.Semantic proximity Read ↗

Presentation of a kindred with familial medullary thyroid carcinoma and Cys611Phe mutation of the RET proto-oncogene demonstrating low grade malignancy.Semantic proximity Read ↗

Multiple endocrine neoplasia type 2: evaluation of the genotype-phenotype relationship.Semantic proximity Read ↗

Genetic testing in medullary thyroid carcinoma syndromes: mutation types and clinical significance.Semantic proximity Read ↗

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