Article
[Study of androgen receptor expression and neuronal vulnerability in X-linked spinal and bulbar muscular atrophy].
[Hokkaido igaku zasshi] The Hokkaido journal of medical science - 1 Nov 1996
Matsuura T
Abstract excerpt
X-linked spinal and bulbar muscular atrophy (SBMA), a rare adult onset form of motor neuron disease, is clinically characterized by slowly progressive muscle weakness and atrophy, and endocrinopathy such as gynecomastia, testicular atrophy and oligospermia. Androgens are known to play an important role in motor neuron growth, development and regeneration. The genetic mutation of androgen receptor (AR) gene in...
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