Article
Two-step delivery of retroviruses to postmitotic, terminally differentiated cells.
Human gene therapy - 1 Jan 1997
Ito M, Kedes L
Abstract excerpt
Recombinant replication-defective retroviral vectors are currently the most commonly used vectors for introducing foreign genes into human cells in gene therapy protocols. Their genomes stably incorporate in the host chromosomes of mitotic cells, thus ensuring stable expression. However, the appl...
Topics
- Adenoviridae
- Animals
- Antigens, Polyomavirus Transforming
- Cell Differentiation
- Cell Division
- Cells, Cultured
- DNA
- Gene Expression Regulation
- Gene Transfer Techniques
- Genetic Vectors
- Histocytochemistry
- Mice
- Mitogens
- Muscles
- Phenotype
- Retroviridae
- beta-Galactosidase