Article
Immune response to cyclin B1 in hepatocellular carcinoma.
Hepatology (Baltimore, Md.) - 1 Jan 1997
Covini G, Chan E K, Nishioka M, Morshed S A, Reed S I, Tan E M
Abstract excerpt
Proteins expressed by plasmids encoding human cyclins and cyclin-dependent kinase 2 (CDK2) were used as antigens in immunoblotting. Fifteen of 100 patients with hepatocellular carcinoma (HCC) were found to have autoantibodies reactive with cyclin B1 and with a 40-kd degradation product of cyclin B1-glutathione-S-transferase (GST) fusion protein. Only one serum was found to react with cyclin A and another single...
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