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Article

Antibodies to Transcobalamin II Block In Vitro Proliferation of Leukemic Cells

1 Jan 1997

Abstract excerpt

The plasma protein transcobalamin II (TCII) binds and delivers cobalamin (Cbl; vitamin B12) to all cells, which internalize the TCII/Cbl complex by receptor-mediated endocytosis. Congenital deficiency of TCII results in intracellular Cbl deficiency, one effect of which is to disrupt DNA synthesis, leading to megaloblastic anemia. We report here an in vitro culture system in which cell growth is dependent on...

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Identifiers

PMID: 8978297
DOI: 10.1182/blood.v89.1.235

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