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Article

Localization of the gene responsible for the op (osteopetrotic) defect in rats on chromosome 10.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Dec 1996

Remmers E F, Du Y, Ding Y P, Kotake S, Ge L, Zha H, Goldmuntz E A, Hansen C, Wilder R L

Abstract excerpt

Osteopetrosis, a skeletal disorder of inadequate bone resorption with an abnormal increase in skeletal mass, results from a variety of independent single gene mutations that affect osteoclast differentiation and/or function. The osteopetrotic defect, op, is one of four spontaneous, nonallelic mutations in rats that result in osteopetrosis. In intercross progeny of (BN/SsN x LEW/SsN. +/op) F1 carriers, we mapped...

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PMID: 8970886
DOI: 10.1002/jbmr.5650111205

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Localization of the gene responsible for the op (osteopetrotic) defect in rats on chromosome 10.PMID 8970886Read ↗

Refined genomic localization of the genetic lesion in the osteopetrosis (op) rat and exclusion of three positional and functional candidate genes, Clcn7, Atp6v0c, and Slc9a3r2.Semantic proximity Read ↗

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SNX10 gene mutation leading to osteopetrosis with dysfunctional osteoclastsSemantic proximity Read ↗

SNX10 mutations define a subgroup of human autosomal recessive osteopetrosis with variable clinical severity.Semantic proximity Read ↗

The osteopetrotic mutation toothless ( tl ) is a loss-of-function frameshift mutation in the rat Csf1 gene: Evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossificationSemantic proximity Read ↗

Mapping of Autosomal Dominant Osteopetrosis Type II (Albers-Schönberg Disease) to Chromosome 16p13.3Semantic proximity Read ↗

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Localization of a Gene for Autosomal Dominant Osteopetrosis (Albers-Schönberg Disease) to Chromosome 1p21Semantic proximity Read ↗

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