Article
Structure-function correlations of the insulin-linked polymorphic region.
Journal of molecular biology - 6 Dec 1996
Catasti P, Chen X, Moyzis R K, Bradbury E M, Gupta G
Abstract excerpt
The insulin minisatellite of the insulin-linked polymorphic region (ILPR), a 14 base-pairs long tandem repeat of: 5'-ACAGGGGTGTGGGG-3' 3'-TGTCCCCACACCCC-5', is located 363 base-pairs upstream of the human insulin gene. A locus for insulin-dependent diabetes mellitus (IDDM) has been mapped to the ILPR. It has been shown that the ILPR is polymorphic in length and this length polymorphism is also related to the...
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