Article
The sarcoglycan complex in the six autosomal recessive limb-girdle muscular dystrophies.
Human molecular genetics - 1 Dec 1996
Vainzof M, Passos-Bueno M R, Canovas M, Moreira E S, Pavanello R C, Marie S K, Anderson L V, Bonnemann C G, McNally E M, Nigro V, Kunkel L M, Zatz M
Abstract excerpt
To enhance our understanding of the autosomal recessive limb-girdle muscular dystrophy (LGMD), patients from six genetically distinct forms (LGMD2A to LGMD2F) were studied with antibodies directed against four sarcoglycan subunits (alpha-, beta-, gamma-, delta-SG), dystrophin, beta-dystroglycan (beta-DG) and merosin. All patients with LGMD2A and 2B had a mild clinical course while those with a primary sarcoglycan...
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