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Article

Neurophysins in central diabetes insipidus.

Hormone research - 1 Jan 1996

Legros J J, Geenen V

Abstract excerpt

When they were discovered by Acher and co-workers, neurophysins were thought to act as carriers for the active nonapeptides vasopressin (AVP) and oxytocin (OT) and were then recognized as the inactive fragment of a precursor with a higher molecular weight (propressophysin). The role of neurophysins in the hypothalamo-neurohypophyseal system is now being reconsidered in the light of crystallographic and molecular...

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Identifiers

PMID: 8964580
DOI: 10.1159/000184784

Genes

AVP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 8 closest

Neurophysins in central diabetes insipidus.PMID 8964580Read ↗

A diabetes insipidus vasopressin prohormone altered outside the central core of neurophysin accumulates in the endoplasmic reticulum.Semantic proximity Read ↗

Autosomal dominant neurohypophyseal diabetes insipidus associated with a missense mutation encoding Gly23-->Val in neurophysin II.Semantic proximity Read ↗

Effects of diabetes insipidus mutations on neurophysin folding and function.Semantic proximity Read ↗

Effects of aging on vasopressin production in a kindred with autosomal dominant neurohypophyseal diabetes insipidus due to the DeltaE47 neurophysin mutation.Semantic proximity Read ↗

The molecular biology of human hereditary central diabetes insipidus.Semantic proximity Read ↗

Effects of various mutations in the neurophysin/glycopeptide portion of the vasopressin gene on vasopressin expression in vitro.Semantic proximity Read ↗

Differential neurophysin immunoreactivities in solitary magnocellular neurons of the homozygous Brattleboro rat indicate an altered neurophysin moiety.Semantic proximity Read ↗

A missense mutation encoding cys(67) --> gly in neurophysin ii is associated with early onset autosomal dominant neurohypophyseal diabetes insipidus.Semantic proximity Read ↗

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