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Article

Effects of diabetes insipidus mutations on neurophysin folding and function.

The Journal of biological chemistry - 10 Aug 2001

Eubanks S, Nguyen T L, Deeb R, Villafania A, Alfadhli A, Breslow E

Abstract excerpt

Mechanisms underlying the pathogenicity of diabetes insipidus mutations were probed by studying their effects on the properties of bovine oxytocin-related neurophysin. The mutations G17V, DeltaE47, G57S, G57R, and C67STOP were each shown to have structural consequences that would diminish the conformational stability and folding efficiency of the precursors in which they were incorporated, and factors...

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Identifiers

PMID: 11395505
DOI: 10.1074/jbc.M103477200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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