Article
Genetic counseling in hereditary nonpolyposis colorectal cancer: an extended family with MSH2 mutation.
The American journal of gastroenterology - 1 Dec 1996
Lynch H T, Lemon S, Smyrk T, Franklin B, Karr B, Lynch J, Slominski-Caster S, Murphy P, Connolly C
Abstract excerpt
OBJECTIVES: Molecular genetic advances have increased the demand for DNA testing. We describe DNA based genetic counseling in a hereditary nonpolyposis colorectal cancer (HNPCC) family. METHODS: This extended HNPCC family was found to harbor the MSH2 germline mutation. Family history, medical, an...
Topics
- Adult
- Aged
- Colorectal Neoplasms
- Female
- Genetic Counseling
- Genotype
- Heterozygote
- Humans
- Male
- Middle Aged
- Mutation
- Phenotype
- Reproduction
- Stress, Psychological