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Article

The role of protein tyrosine phosphatase SHP-1 in the regulation of IFN-gamma signaling in neural cells.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 1996

Massa P T, Wu C

Abstract excerpt

The role for protein tyrosine phosphatase SHP-1 in controlling signal transduction by IFN-gamma in astrocytes was studied. IFN-gamma induced the gamma-activated factor (GAF) within 30 min and GAF subsequently declined by 8 h after treatment. However, treatment with IFN-gamma in the presence of protein tyrosine phosphatase inhibitor vanadate blocked the decrease in GAF activity. The increased stability of GAF in...

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PMID: 8943425

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The role of protein tyrosine phosphatase SHP-1 in the regulation of IFN-gamma signaling in neural cells.PMID 8943425Read ↗

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Stat1 α expression is involved in IFN-γ induction of the class II transactivator and class II MHC genesSemantic proximity Read ↗

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