Article
Viral dynamics of hepatitis C early after orthotopic liver transplantation: evidence for rapid turnover of serum virions.
Hepatology (Baltimore, Md.) - 1 Dec 1996
Fukumoto T, Berg T, Ku Y, Bechstein W O, Knoop M, Lemmens H P, Lobeck H, Hopf U, Neuhaus P
Abstract excerpt
The pathogenesis of hepatitis C virus (HCV) infection is likely to be associated with viral replication in vivo, but little is known concerning the dynamics of HCV turnover. We performed serial measurements of serum HCV-RNA levels following orthotopic liver transplantation (OLT) in nine patients with HCV-positive cirrhosis. Serum HCV-RNA levels were determined by quantitative polymerase chain reaction before,...
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