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Article

The alpha-helix of ribonuclease T1 as an independent stability unit: direct comparison of peptide and protein stability.

Journal of molecular biology - 1 Nov 1996

Myers J K, Smith J S, Pace C N, Scholtz J M

Abstract excerpt

Measurements of the change in conformational stability, delta(delta G), upon mutation of two acidic residues at the C terminus of the helix of ribonuclease T1 have recently been reported. Here, we investigate peptides based on the sequence of the helix with the same mutations: Glu28 replaced with Gln, Asp29 replaced with Asn, and the double mutant. In addition, the mutant Lys25 to Gln was studied. Changes in...

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Source

Identifiers

PMID: 8918595
DOI: 10.1006/jmbi.1996.0583

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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