Optimal sequencing strategies for surveying molecular genetic diversity.

doi:10.1093/genetics/144.3.1247

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Article

Optimal sequencing strategies for surveying molecular genetic diversity.

Genetics - 1 Nov 1996

Pluzhnikov A, Donnelly P

Abstract excerpt

Two commonly used measures of genetic diversity for intraspecies DNA sequence data are based, respectively, on the number of segregating sites, and on the average number of pairwise nucleotide differences. Expressions are derived for their variance in the presence of intragenic recombination for a panmictic population of fixed size that is at neutral equilibrium at the region sequenced. We show that, in contrast...

Topics

DNA
Genetic Variation
Mathematical Computing
Recombination, Genetic

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Identifiers

PMID: 8913765
DOI: 10.1093/genetics/144.3.1247
PMCID: PMC1207616

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