Use of a highly purified alpha 1-antitrypsin standard to establish ranges for the common normal and deficient alpha 1-antitrypsin phenotypes.

doi:10.1378/chest.100.3.703

Back to search

Article

Use of a highly purified alpha 1-antitrypsin standard to establish ranges for the common normal and deficient alpha 1-antitrypsin phenotypes.

Chest - 1 Sept 1991

Brantly M L, Wittes J T, Vogelmeier C F, Hubbard R C, Fells G A, Crystal R G

Abstract excerpt

Diagnosis of the hereditary disorder alpha 1-antitrypsin (alpha 1AT) deficiency is critically dependent on quantification of serum levels of alpha 1AT, a 52-kDa antiprotease that serves to protect the lung from destruction by neutrophil elastase. Although the measurement of serum alpha 1AT levels...

Topics

Electrophoresis, Polyacrylamide Gel
Humans
Phenotype
Reference Values
alpha 1-Antitrypsin
alpha 1-Antitrypsin Deficiency

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.