Signal transduction: specificity of growth factors explained by parallel distributed processing.

Abstract excerpt

Mutations in proteins of receptor tyrosine kinase signalling pathways might change signalling properties and contribute to the progression towards neoplasia. Ligands for these receptors (growth factors) which elicit the same signal transducing cascades can trigger different developmental pathways in identical cells. For example, PC12 cells differentiate after treatment with NGF, but proliferate after stimulation...

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