A long-term culture system for the expansion of hematopoietic stem cells from embryonic yolk sac with the capacity to seed erythroid and lymphoid development in vitro and to reconstitute the lymphoid compartment in severe combined immunodeficient mice.

doi:10.1111/j.1525-1594.1996.tb00644.x

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Article

A long-term culture system for the expansion of hematopoietic stem cells from embryonic yolk sac with the capacity to seed erythroid and lymphoid development in vitro and to reconstitute the lymphoid compartment in severe combined immunodeficient mice.

Artificial organs - 1 Oct 1996

Ji H, Yu X Z, Wagner T E

Abstract excerpt

We have established a long-term culture system under which hematopoietic stem cells derived from the embryonic yolk sac may be maintained for long periods. Evidence for the persistence of stem cells in this culture is provided by three experimental observations. First, erythroid progenitors, as e...

Topics

Animals
Base Sequence
CHO Cells
Cell Division
Cell Transplantation
Cells, Cultured
Cricetinae
Fibroblast Growth Factor 2
Gene Expression Regulation, Developmental
Globins
Granulocyte-Macrophage Colony-Stimulating Factor
Hematopoietic Stem Cells
Interleukins

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphoid Tissue

Mice

Phenotype

Polymerase Chain Reaction

Recombinant Proteins

Source

Open in PubMed

Identifiers

PMID: 8896728
DOI: 10.1111/j.1525-1594.1996.tb00644.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8896728-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.