Article
Heparin binds to the laminin alpha4 chain LG4 domain at a site different from that found for other laminins.
Journal of molecular biology - 30 Jan 2004
Yamashita Hironobu, Beck Konrad, Kitagawa Yasuo
Abstract excerpt
We previously reported that the LG4 domain of the laminin alpha4 chain is responsible for high-affinity heparin binding. To specify the amino acid residues involved in this activity, we produced a series of alpha4 LG4-fusion proteins in which each of the 27 basic residues (arginine, R; histidine;...
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