Article
Progression to persistent lymphocytosis and tumor development in bovine leukemia virus (BLV)-infected cattle correlates with impaired proliferation of CD4+ T cells in response to gag- and env-encoded BLV proteins.
Journal of virology - 1 Nov 1996
Orlik O, Splitter G A
Abstract excerpt
The mechanism of leukemogenesis and persistent lymphocytosis (PL; benign expansion of B lymphocytes) in cattle infected with bovine leukemia virus (BLV; a retrovirus closely related to human T-cell leukemia virus type 1) is unknown; however, the immune system likely plays an important role in con...
Topics
- Animals
- Antigens, Viral
- CD4-Positive T-Lymphocytes
- Cattle
- Cell Division
- Cell Line
- Cells, Cultured
- Disease Progression
- Enzootic Bovine Leukosis
- Gene Expression
- Gene Products, env
- Gene Products, gag
- Leukemia Virus, Bovine
- Lymphocytosis
- Phenotype