Article
Six newly identified HLA-DRB alleles: DRB1*1121, *1419, *1420, *1421, DRB3*0203 and DRB5*0103.
Tissue antigens - 1 Aug 1996
Verduyn W, Anholts J D, Versluis L F, Parlevliet J, Drabbels J, De Meester J, Tilanus M G, Doxiadis I I, Giphart M J, Schreuder G M
Abstract excerpt
Seven samples with irregular PCR-SSO hybridization patterns, observed during routine HLA-DRB typing, were studied in more detail. Group-specific amplification, followed by hybridization with relevant SSOs strengthened the suggestion that these samples contained new DRB alleles. DRB exon 2 segments were amplified, cloned and sequenced and revealed: DRB1*1121 [MUL] is similar to DRB1*1102 in which codon 85 changed...
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