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Article

Different PrlA proteins increase the efficiency of periplasmic production of human interleukin-6 in Escherichia coli.

Journal of biotechnology - 20 Aug 1996

Pérez-Pérez J, Barbero J L, Márquez G, Gutiérrez J

Abstract excerpt

The export efficiency of a fusion of the Escherichia coli preOmpA signal peptide to human interleukin-6 can be significantly raised by coexpressing three different prlA alleles of sec Y along with wild type secE. The effect seems prlA-specific, as prlG1 (a prl allele of secE) does not affect the export of preOmpA-hIL-6. Coexpression of secD and secF also stimulates the export of the fusion protein.

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Identifiers

PMID: 8879175
DOI: 10.1016/0168-1656(96)83990-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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