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Article

The solved and unsolved mysteries of the genetics of early-onset Alzheimer's disease.

Neuromolecular medicine - 1 Jan 2002

Rogaeva Ekaterina

Abstract excerpt

Approximately half of the Alzheimer's disease (AD) cases that are associated with early onset appear to be transmitted as a pure genetic, autosomal dominant trait. Genetic analyses of these pedigrees have found three causal genes: betaAPP, presenilin 1 (PS1), and presenilin 2 (PS2). This review provides an update on the pathological consequences of mutations in early-onset AD genes, the phenotypic heterogeneity...

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PMID: 12230301
DOI: 10.1385/NMM:2:1:01

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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