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Article

Decrease in exploratory behavior in naturally occurring cholecystokinin (CCK)-A receptor gene knockout rats.

Neuroscience letters - 16 Aug 1996

Kobayashi S, Ohta M, Miyasaka K, Funakoshi A

Abstract excerpt

We recently found a specific strain of rats (Otsuka Long Evans Tokushima Fatty; OLETF rats) lacking cholecystokinin (CCK)-A receptor because of a genetic abnormality. Since CCK is an abundant neurotransmitter peptide in the brain, we examined whether these animals exhibit any behavioral abnormalities by conducting open-field tests. OLETF rats showed hypolocomotor activity and a decrease in the incidence of...

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Source

Identifiers

PMID: 8873132
DOI: 10.1016/0304-3940(96)12881-0

Genes

CCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Decrease in exploratory behavior in naturally occurring cholecystokinin (CCK)-A receptor gene knockout rats.PMID 8873132Read ↗

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Phenotypes of mice with invalidation of cholecystokinin (CCK(1) or CCK(2)) receptors.Semantic proximity Read ↗

Absence of the cholecystokinin-A receptor deteriorates homeostasis of body temperature in response to changes in ambient temperature.Semantic proximity Read ↗

Different housing conditions alter the behavioural phenotype of CCK(2) receptor-deficient mice.Semantic proximity Read ↗

Susceptibility to the development of gastric mucosal damage in OLETF rat not expressing the CCK-A receptor.Semantic proximity Read ↗

Targeted mutation of CCK(2) receptor gene antagonises behavioural changes induced by social isolation in female, but not in male mice.Semantic proximity Read ↗

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