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Article

Suppression of CD8+ T-cell recognition in the immediate-early phase of human cytomegalovirus infection

25 Oct 2012

Abstract excerpt

Human cytomegalovirus (HCMV) interferes with MHC class I-restricted antigen presentation and thereby reduces recognition by CD8(+) T-cells. This interference is mediated primarily by endoplasmic reticulum-resident glycoproteins that are encoded in the US2-11 region of the viral genome. Such a suppression of recognition would be of particular importance immediately after infection, because several immunodominant...

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PMID: 23100361
DOI: 10.1099/vir.0.045682-0

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