Article
Reactions of hydrogen peroxide with familial amyotrophic lateral sclerosis mutant human copper-zinc superoxide dismutases studied by pulse radiolysis.
The Journal of biological chemistry - 13 Nov 1998
Goto J J, Gralla E B, Valentine J S, Cabelli D E
Abstract excerpt
Mutations in copper-zinc superoxide dismutase (CuZn-SOD) have been implicated in the familial form of the motor neuron disease amyotrophic lateral sclerosis (Lou Gehrig's disease). We have expressed and purified recombinant human wild type (hWT) and G93A (hG93A) CuZn-SOD, and we have used pulse r...
Topics
- Amyotrophic Lateral Sclerosis
- Binding Sites
- Catalysis
- Hot Temperature
- Humans
- Hydrogen Peroxide
- Mutation
- Pulse Radiolysis
- Saccharomyces cerevisiae
- Spectrophotometry, Atomic
- Superoxide Dismutase