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Article

A3 domain is essential for interaction of von Willebrand factor with collagen type III.

Thrombosis and haemostasis - 1 Jun 1996

Lankhof H, van Hoeij M, Schiphorst M E, Bracke M, Wu Y P, Ijsseldijk M J, Vink T, de Groot P G, Sixma J J

Abstract excerpt

von Willebrand factor (vWF) mediates platelet adhesion at sites of vascular damage. It acts as a bridge between receptors on platelets and collagens present in the connective tissue. Two collagen binding sites have been identified on the A1 and A3 domain of the vWF subunit. To study the functional importance of these binding sites, we have made two deletion mutants that lack the A1 domain (residues 478-716; delta...

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PMID: 8822592

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

A3 domain is essential for interaction of von Willebrand factor with collagen type III.PMID 8822592Read ↗

Identification of the collagen-binding site of the von Willebrand factor A3-domain.Semantic proximity Read ↗

M1761K mutation in the von Willebrand factor A3 domain associated with impaired collagen binding and without platelet dysfunction.Semantic proximity Read ↗

Shielding of the A1 domain by the D'D3 domains of von Willebrand factor modulates its interaction with platelet glycoprotein Ib-IX-V.Semantic proximity Read ↗

Crucial role for the VWF A1 domain in binding to type IV collagen.Semantic proximity Read ↗

Recombinant von Willebrand factor Arg578-->Gln. A type IIB von Willebrand disease mutation affects binding to glycoprotein Ib but not to collagen or heparin.Semantic proximity Read ↗

The interaction of integrin αIIbβ3 with fibrin occurs through multiple binding sites in the αIIb β-propeller domain.Semantic proximity Read ↗

The physical spacing between the von Willebrand factor D'D3 and A1 domains regulates platelet adhesion in vitro and in vivo.Semantic proximity Read ↗

The defective interaction between von Willebrand factor and factor VIII in a patient with type 1 von Willebrand disease is caused by substitution of Arg19 and His54 in mature von Willebrand factor.Semantic proximity Read ↗

Crystal structure of the von Willebrand Factor A1 domain and implications for the binding of platelet glycoprotein Ib.Semantic proximity Read ↗

O-linked glycosylation of von Willebrand factor modulates the interaction with platelet receptor glycoprotein Ib under static and shear stress conditions.Semantic proximity Read ↗

Amino acid mutagenesis within ligand-binding loops in alpha v confers loss-of-function or gain-of-function phenotype on integrin alpha v beta 3.Semantic proximity Read ↗

Major mutations in calf-1 and calf-2 domains of glycoprotein IIb in patients with Glanzmann thrombasthenia enable GPIIb/IIIa complex formation, but impair its transport from the endoplasmic reticulum to the Golgi apparatus.Semantic proximity Read ↗

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