Structure and mode of action of kikA, a genetic region lethal to Klebsiella oxytoca and associated with conjugative antibiotic-resistance plasmids of the IncN group.

Abstract excerpt

Transmission of conjugative plasmids of the IncN group into Klebsiella oxytoca, but not into Escherichia coli, results in the marked reduction of viability of the recipients. In the plasmid pCU1 a 500-bp locus called kikA has the major role in determining this phenotype. Expression of two open reading frames (orf104 and orf70) is required for the Kik+ phenotype and they can function in cis or in trans. orf104...

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