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Article

The Initial Molecular Interaction between Mouse Sperm and the Zona Pellucida Is a Complex Binding Event

1 Sept 1996

Abstract excerpt

Prior to fertilization, mammalian sperm must first bind to the zona pellucida (ZP), a glycoprotein matrix surrounding the egg. Sperm specifically bind to ZP3, an 83-kDa glycoprotein which functions as both an adhesion molecule and as a secretagogue for acrosomal exocytosis (Litscher, E. S., and Wassarman, P. M. (1993) Trends Glycosci. Glycotechnol. 5, 369-388). We used acid solubilized, 125I-labeled ZPs to...

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PMID: 8798528
DOI: 10.1074/jbc.271.38.23289

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