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Article

PCR engineering of viral quasispecies: a new method to preserve and manipulate genetic diversity of RNA virus populations.

Journal of virology - 1 Oct 1996

Chumakov K M

Abstract excerpt

A PCR-based method for the controlled manipulation of individual genomic sites of poliovirus with concomitant preservation of the sequence heterogeneity of the rest of the genome is proposed. The new approach can be used for the creation of stable DNA repositories of populations of extremely heterogenous RNA viruses and may have implications for live vaccine technology.

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Identifiers

PMID: 8794393
DOI: 10.1128/JVI.70.10.7331-7334.1996
PMCID: PMC190799

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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