Article
Monitoring human exposure to 2-hydroxyethylating carcinogens.
Environmental health perspectives - 1 May 1996
Farmer P B, Cordero R, Autrup H
Abstract excerpt
It is known that human hemoglobin contains low levels of N-terminal N-(2-hydroxyethyl)valine. Possible sources of this modified amino acid are exposure to ethylene oxide or other 2-hydroxy-ethylating agents. Although such processes are likely to occur endogenously, the exogenous contribution to the adduct formation is unclear. In order to explore the latter, we have analyzed N-(2-hydroxyethyl)valine in the globin...
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