Article
Hepatitis B virus carriers without precore mutations in hepatitis B e antigen-negative stage show more severe liver damage.
Hepatology (Baltimore, Md.) - 1 Sept 1996
Lindh M, Horal P, Dhillon A P, Furuta Y, Norkrans G
Abstract excerpt
Hepatitis B e antigen (HBeAg) is considered to be a major target for the immune response in chronic hepatitis B. The G-->A mutation at nucleotide 1896 may mediate viral escape by creating a TAG stop codon in the precore region, thus preventing HBeAg production. This mutation frequently evolves during HBe seroconversion if thymine, but rarely if cytosine, is present in position 1858. Applying a combination of...
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