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Article

Hypertrophic Cardiomyopathy: Genes and Mechanisms.

Frontiers in bioscience (Landmark edition) - 12 Feb 2025

Chen Jinli, Xing Yang, Sun Jie, Liu Yongming, Lang Zekun, Zhang Lei, Yang Jinggang

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is a hereditary disease of the myocardium characterized by asymmetric hypertrophy (mainly the left ventricle) not caused by pressure or volume load. Most cases of HCM are caused by genetic mutations, particularly in the gene encoding cardiac myosin, such as MYH7, TNNT2, and MYBPC3. These mutations are usually inherited autosomal dominantly. Approximately 30-60% of HCM patients...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40018920
DOI: 10.31083/FBL25714

Genes

MYBPC3
MYH7
TNNT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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