Article
Phenotypic alteration of a human BK (hSlo) channel by hSlobeta subunit coexpression: changes in blocker sensitivity, activation/relaxation and inactivation kinetics, and protein kinase A modulation.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Aug 1996
Dworetzky S I, Boissard C G, Lum-Ragan J T, McKay M C, Post-Munson D J, Trojnacki J T, Chang C P, Gribkoff V K
Abstract excerpt
A human homolog of the large-conductance calcium-activated potassium (BK) channel beta subunit (hSlobeta) was cloned, and its effects on a human BK channel (hSlo) phenotype are reported. Coexpression of hSlo and hSlobeta, in both oocytes and human embryonic kidney 293 cells, resulted in increased Ca2+ sensitivity, marked slowing of BK channel activation and relaxation, and significant reduction in slow...
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