Article
Truncation at conserved terminal regions of BRCA1 protein is associated with highly proliferating hereditary breast cancers.
Cancer research - 15 Jul 1996
Sobol H, Stoppa-Lyonnet D, Bressac-de-Paillerets B, Peyrat J P, Kerangueven F, Janin N, Noguchi T, Eisinger F, Guinebretiere J M, Jacquemier J, Birnbaum D
Abstract excerpt
The existence of two subgroups of BRCA1-associated breast cancer (BC) families has been recently posited: the first with highly proliferating tumors, and the second composed of cases with a low proliferation rate. Our aim was to test whether the proliferation rate of BRCA1-associated breast cancers was affected by the site of the germ line mutation in the BRCA1 gene. We analyzed the distribution of the mitotic...
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