Herpes simplex virus type 1 protein IE63 affects the nuclear export of virus intron-containing transcripts.

doi:10.1128/JVI.70.8.5255-5265.1996

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Article

Herpes simplex virus type 1 protein IE63 affects the nuclear export of virus intron-containing transcripts.

Journal of virology - 1 Aug 1996

Phelan A, Dunlop J, Clements J B

Abstract excerpt

Using in situ hybridization labelling methods, we have determined that the herpes simplex virus type 1 immediate-early protein IE63 (ICP27) affects the cellular localization of virus transcripts. Intronless transcripts from the IE63, UL38, and UL44 genes are rapidly exported to and accumulate in...

Topics

Biological Transport
Cell Nucleus
HeLa Cells
Herpes Simplex
Humans
Immediate-Early Proteins
In Situ Hybridization
Mutation
Simplexvirus
Trans-Activators

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