Article
Urease activity does not contribute dramatically to persistence of Mycobacterium bovis bacillus Calmette-Guérin.
Infection and immunity - 1 Sept 1996
Reyrat J M, Lopez-Ramirez G, Ofredo C, Gicquel B, Winter N
Abstract excerpt
Multiplication of BCGure-, an isogenic urease-negative mutant of Mycobacterium bovis BCG constructed by allelic exchange (J. M. Reyrat, F. X. Berthet, and B. Gicquel, Proc. Natl. Acad. Sci. USA 92:8768-8772, 1995), was examined in human macrophages and mice. Although ureolytic activity was not essential to BCGure-growth, a slight decrease in the multiplication and persistence of the mutated strain compared with...
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