Article
Dopamine DRD4 receptor polymorphism and attention deficit hyperactivity disorder.
Molecular psychiatry - 1 Sept 1998
Rowe D C, Stever C, Giedinghagen L N, Gard J M, Cleveland H H, Terris S T, Mohr J H, Sherman S, Abramowitz A, Waldman I D
Abstract excerpt
A polymorphism in the dopamine receptor 4 gene (DRD4) has been related to novelty seeking, Tourette's syndrome, and attention deficit hyperactivity disorder (ADHD). The variability is in a 48-bp repeat in exon 3 of the gene (a transmembrane region). This study examined the relation of the 7-repeat (i.e., high-risk) allele to questionnaire-based diagnoses of ADHD (both combined type and inattentive type). Several...
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