Improvement of the Brucella abortus B19 vaccine by its preparation in a glycerol based medium.

doi:10.1016/0264-410x(95)00214-l

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Article

Improvement of the Brucella abortus B19 vaccine by its preparation in a glycerol based medium.

Vaccine - 1 Mar 1996

Sangari F J, Agüero J, García-Lobo J M

Abstract excerpt

The Brucella abortus B19 vaccine strain differs from other Brucella strains in its sensitivity to erythritol. However, erythritol tolerant (Eri(t)) mutants arise from sensitive cultures of B19 at high rate, and may cause persistence and/or abortion when the vaccine is inoculated on adult cattle....

Topics

Animals
Brucella Vaccine
Brucella abortus
Cattle
Drug Resistance, Microbial
Erythritol
Glycerol
Mutation

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