Article
Improvement of the Brucella abortus B19 vaccine by its preparation in a glycerol based medium.
Vaccine - 1 Mar 1996
Sangari F J, Agüero J, García-Lobo J M
Abstract excerpt
The Brucella abortus B19 vaccine strain differs from other Brucella strains in its sensitivity to erythritol. However, erythritol tolerant (Eri(t)) mutants arise from sensitive cultures of B19 at high rate, and may cause persistence and/or abortion when the vaccine is inoculated on adult cattle. Twelve different batches of B19 have been examined for the presence of Eri(t) mutants. All contained Eri(t) variants at...
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