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Article

<i>In Vitro</i> Evidence That Metabolic Cooperation Is Responsible for the Bystander Effect Observed with HSV <i>tk</i> Retroviral Gene Therapy

1 Dec 1993

Abstract excerpt

Tumor cells transduced with a retroviral vector expressing a herpes virus thymidine kinase (HSV tk) gene are rendered sensitive to the antiherpetic drug, ganciclovir. The bystander effect refers to the observation that not all cells need be transduced to eradicate the cell population by treatment with ganciclovir. We demonstrate that metabolic cooperation can account for this bystander effect. When HT1080 human...

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Identifiers

PMID: 8186287
DOI: 10.1089/hum.1993.4.6-725

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