Article
Expression and production of cytokines by heterohybrids and their parental B cells in CLL.
Leukemia & lymphoma - 1 Apr 1996
Diaw L, Lefebvre d'Hellencourt C, Cornillet I, Vuillier F, Guenounou M, Dighiero G
Abstract excerpt
Three hybrids derived from CD5+ B cell chronic lymphocytic leukemia (B-CLL) and their parental B cells were studied for phenotypic evolution, immunoglobulin (Ig), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) secretion. When phenotypic evolution was examined, hybrids showed the...
Topics
- B-Lymphocytes
- Blotting, Southern
- Chromosome Deletion
- Down-Regulation
- Gene Expression Regulation, Leukemic
- Humans
- Hybrid Cells
- Immunoglobulin M
- Interleukin-6
- Karyotyping
- Leukemia, Lymphocytic, Chronic, B-Cell
- Phenotype
- RNA, Messenger
- Tumor Cells, Cultured
- Tumor Necrosis Factor-alpha