Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Drosophila singed, a fascin homolog, is required for actin bundle formation during oogenesis and bristle extension.

The Journal of cell biology - 1 Apr 1994

Cant K, Knowles B A, Mooseker M S, Cooley L

Abstract excerpt

Drosophila singed mutants were named for their gnarled bristle phenotype but severe alleles are also female sterile. Recently, singed protein was shown to have 35% peptide identity with echinoderm fascin. Fascin is found in actin filament bundles in microvilli of sea urchin eggs and in filopodial...

Topics

Actins
Animals
Antibodies, Monoclonal
Blotting, Western
Carrier Proteins
Cloning, Molecular
Cytoplasm
Drosophila
Female
Insect Hormones
Microfilament Proteins
Oogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ovary

Phenotype

Recombinant Proteins

Sequence Homology

Source

Open in PubMed Open full text

Identifiers

PMID: 8163553
DOI: 10.1083/jcb.125.2.369
PMCID: PMC2120035

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8163553-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Drosophila singed, a fascin homolog, is required for actin bundle formation during oogenesis and bristle extension.PMID 8163553Read ↗

Single amino acid mutations in Drosophila fascin disrupt actin bundling function in vivo.Semantic proximity Read ↗

Drosophila fascin mutants are rescued by overexpression of the villin-like protein, quail.Semantic proximity Read ↗

Changes in the F-actin cytoskeleton during neurosensory bristle development in Drosophila: the role of singed and forked proteins.Semantic proximity Read ↗

Drosophila Fascin is a novel downstream target of prostaglandin signaling during actin remodeling.Semantic proximity Read ↗

Why are two different cross-linkers necessary for actin bundle formation in vivo and what does each cross-link contribute?Semantic proximity Read ↗

F actin bundles in Drosophila bristles. I. Two filament cross-links are involved in bundling.Semantic proximity Read ↗

Expression of the 53 kD forked protein rescues F-actin bundle formation and mutant bristle phenotypes in Drosophila.Semantic proximity Read ↗

The Drosophila javelin gene encodes a novel actin-associated protein required for actin assembly in the bristle.Semantic proximity Read ↗

The tricornered gene, which is required for the integrity of epidermal cell extensions, encodes the Drosophila nuclear DBF2-related kinase.Semantic proximity Read ↗

Roles of NUDE and NUDF proteins of Aspergillus nidulans: insights from intracellular localization and overexpression effects.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.