A congenital heart defect in Drosophila caused by an action-potential mutation.

doi:10.3109/01677069509083461

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Article

A congenital heart defect in Drosophila caused by an action-potential mutation.

Journal of neurogenetics - 1 Dec 1995

Dowse H, Ringo J, Power J, Johnson E, Kinney K, White L

Abstract excerpt

The mutation no action potential (nap) induces arrhythmia in the heartbeat of Drosophila melanogaster larvae at temperatures above 20 degrees C; heartbeat becomes normally rhythmic again after a shift back to 20 degrees C. For this phenotype, napa is almost completely recessive to the wild type,...

Topics

Action Potentials
Animals
Arrhythmias, Cardiac
Drosophila Proteins
Drosophila melanogaster
Epistasis, Genetic
Genes, Insect
Heart Conduction System
Heart Rate
Larva
Myocardial Contraction
Nuclear Proteins
Period Circadian Proteins
Phenotype
Sodium Channels
Temperature

Source

Open in PubMed

Identifiers

PMID: 8719771
DOI: 10.3109/01677069509083461

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8719771-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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