Mutations which introduce free cysteine residues in the Gla-domain of vitamin K dependent proteins result in the formation of complexes with alpha 1-microglobulin.

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Article

Mutations which introduce free cysteine residues in the Gla-domain of vitamin K dependent proteins result in the formation of complexes with alpha 1-microglobulin.

Thrombosis and haemostasis - 1 Jan 1996

Wojcik E G, Simioni P, d Berg M, Girolami A, Bertina R M

Abstract excerpt

We have previously described a genetic factor IX variant (Cys18-->Arg) for which we demonstrated that it had formed a heterodimer with alpha 1-microglobulin through formation of a disulphide bond with the remaining free cysteine residue of the disrupted disulphide bond in the Gla-domain of factor...

Topics

Alpha-Globulins
Amino Acid Sequence
Blood Coagulation Factors
Cysteine
Humans
Molecular Sequence Data
Molecular Weight
Mutation
Osteocalcin
Vitamin K

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Open in PubMed

Identifiers

PMID: 8713782

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8713782-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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