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Article

Promoter switching in Epstein-Barr virus during the initial stages of infection of B lymphocytes.

Proceedings of the National Academy of Sciences of the United States of America - 1 Mar 1990

Woisetschlaeger M, Yandava C N, Furmanski L A, Strominger J L, Speck S H

Abstract excerpt

Transcription of the genes encoding the six viral nuclear antigens present in Epstein-Barr virus latently infected lymphocytes can be initiated from one of two promoters (Cp and Wp) mapping near the left end of the viral genome. These promoters are used in a mutually exclusive manner in clonal cell lines established from either Burkitt lymphoma tumors or in vitro infection of peripheral B lymphocytes. In this...

Topics

Adult
Antigens, Viral
B-Lymphocytes
Base Sequence
Blotting, Southern
Cell Line
Cell Transformation, Viral
Epstein-Barr Virus Nuclear Antigens
Genes, Viral
Herpesvirus 4, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Molecular Sequence Data

Mutation

Oligonucleotide Probes

Plasmids

Promoter Regions, Genetic

RNA, Viral

Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 2155423
DOI: 10.1073/pnas.87.5.1725
PMCID: PMC53555

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2155423-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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