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Article

Evidence that filaggrin is a component of cornified cell envelopes in human plantar epidermis

1 Jul 1996

Abstract excerpt

Cornified cell envelope (CE) is generated during the late stages of epidermal differentiation and is made up of proteins covalently linked together by transglutaminases. To determine whether filaggrin is a component of this structure in humans, we analysed highly purified CE from plantar stratum corneum. An immunoelectron microscopy analysis showed specific binding of four different anti-(pro)filaggrin monoclonal...

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PMID: 8694761
DOI: 10.1042/bj3170173

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