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Article

Complementation of an Escherichia coli adhE mutant by the Entamoeba histolytica EhADH2 gene provides a method for the identification of new antiamebic drugs.

Proceedings of the National Academy of Sciences of the United States of America - 25 Jun 1996

Yong T S, Li E, Clark D, Stanley S L

Abstract excerpt

The pathogenic protozoan parasite Entamoeba histolytica, the cause of amebic dysentery and amebic liver abscess, is an obligate anaerobe, and derives energy from the fermentation of glucose to ethanol with pyruvate and acetyl coenzyme A as intermediates. We have isolated EhADH2, a key enzyme in this pathway, that is a NAD+- and Fe2+-dependent bifunctional enzyme with acetaldehyde dehydrogenase and alcohol...

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Share to Cloning, Molecular
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Complementation Test

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Source

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Identifiers

PMID: 8692838
DOI: 10.1073/pnas.93.13.6464
PMCID: PMC39046

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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