Identification of dihydropyrimidine dehydrogenase as a virulence factor essential for the survival ofEntamoeba histolyticain glucose-poor environments

Abstract excerpt

Adaptation to nutritional changes is a key feature for successful survival of a pathogen within its host. The protozoan parasite Entamoeba histolytica normally colonizes the human colon and in rare occasions, this parasite spread to distant organs, such as the liver. E. histolytica obtains most of its energy from the fermentation of glucose into ethanol. In this study, we were intrigued to know how this parasite...

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