Article
Haplotype analysis at the DYT1 locus in Ashkenazi Jewish patients with occupational hand dystonia.
Movement disorders : official journal of the Movement Disorder Society - 1 Mar 1996
Gasser T, Bove C M, Ozelius L J, Hallett M, Charness M E, Hochberg F H, Breakefield X O
Abstract excerpt
Genetic haplotypes at five marker loci that are closely linked to the DYT1 gene on chromosome 9q were determined in 10 Ashkenazi Jewish patients with focal hand dystonia (eight with musician's cramp, two with writer's cramp). The founder haplotype associated with > 90% of cases generalized dyston...
Topics
- Adult
- Aged
- Chromosome Aberrations
- Chromosome Disorders
- Chromosome Mapping
- Chromosomes, Human, Pair 9
- DNA Mutational Analysis
- Dystonia Musculorum Deformans
- Female
- Genes, Dominant
- Genetic Markers
- Handwriting
- Haplotypes
- Humans
- Jews
- Male
- Middle Aged
- Muscle Cramp